Know these on sight
perfect squares1, 4, 9, 16, 25, 36, 49, 64, 81, 100, 121, 144, 169, 196, 225
perfect cubes1, 8, 27, 64, 125, 216, 343, 512, 729, 1000
A variable power is a square when its exponent is even — halve it: √(x10) = x5. It is a cube when the exponent divides by 3 — take a third: the cube root of x12 is x4.
64 is both (82 and 43), so x6 − 64 can be opened either way. Start with the difference of squares — it factors further.