Endocrine and metabolic — hypothyroidism, diabetes, adrenal disease, vitamin B12 and vitamin D deficiency, anaemia.
Neurological — Parkinson disease, stroke, dementia in its early phase, obstructive sleep apnoea.
Occult disease and pain — pancreatic and other cancers, untreated chronic pain.
Medications — interferon, isotretinoin, corticosteroids, some beta blockers, hormonal contraceptives in susceptible people.
Substances — alcohol above all — a depressant that people frequently use to treat the very symptoms it deepens — plus sedatives and stimulant withdrawal.