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Microbiology · Chapter 12

Interferons — the Antiviral Alarm

A virus hides inside a cell, where barriers, phagocytes, and complement cannot reach it. So the infected cell sends a warning instead. It releases type I interferon, and the neighbors switch on an antiviral state before the virus ever arrives. It is a race. Run it and see who wins.

A sheet of cellshour 0

The sheet of cells, hour by hour
Healthy Warned, antiviral state Infected Dead
One cell is infected. The clock has not started.

The race, hour by hourlive model

Cells lost against cells protected
The antiviral alarmpress Run to start the clock
How strong is the interferon signal
65%
Still healthy
62
Protected
0
Infected or dead
1

What interferon actually does

Type I interferons are IFN-α and IFN-β. An infected cell makes them and sends them out. They do not save that cell. They warn the cells around it.
A warned cell enters an antiviral state. It builds enzymes that chew up viral genetic material, and it is ready to shut protein building down. A virus that gets in finds no factory to hijack.
IFN-γ is a different job. It mainly activates macrophages and bridges over to adaptive immunity.
Interferons are why a viral illness feels awful. Much of the fever, the aches, and the dragging tiredness of influenza is your own interferon at work, not the virus directly.
They are also medicines. Purified interferons treat certain viral hepatitis infections, some cancers, and multiple sclerosis.